Prempro Low Dose (Oral)
Generic name: conjugated estrogens and medroxyprogesterone (oral route) [ KON-joo-gay-ted-ES-troe-jenz, me-drox-ee-proe-JES-ter-one-AS-e-tate ]
Drug class:Sex hormone combinations
Medically reviewed by Drugs.com. Last updated on Jun 5, 2022.
Estrogen with or without progestin should not be used for the prevention of cardiovascular disease or dementia. Increased risks of stroke and deep vein thrombosis in postmenopausal women (50 to 79 years) using estrogen alone have been reported. Increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and DVT in postmenopausal women (50 to 79 years) using estrogen combined with progestin have been reported. An increased risk of developing probable dementia in postmenopausal women 65 years or older has also been reported in women receiving estrogen alone or estrogen combined with progestin. Unopposed estrogens increase the risk of endometrial cancer. Adding a progestin will reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Diagnostic measures should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding. Risks should be assumed to be similar for other doses, combinations, and dosage forms of estrogens and progestins. Estrogens, with or without progestins, should be prescribed at the lowest effective doses and for the shortest duration possible .
Commonly used brand name(s)
In the U.S.
- Premphase
- Prempro
- Prempro Low Dose
Available Dosage Forms:
- Tablet
Therapeutic Class: Estrogen/Progestin Combination
Pharmacologic Class: Estrogen
Uses for Prempro Low Dose
Conjugated estrogens and medroxyprogesterone acetate combination is used to treat moderate to severe hot flashes, dryness in and around the vagina, and other symptoms of menopause. This medicine is also used to prevent osteoporosis (thinning of the bones) after menopause.
This medicine is available only with your doctor's prescription.
Before using Prempro Low Dose
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Conjugated estrogens and medroxyprogesterone acetate combination is not recommended for children.
Geriatric
Although appropriate studies on the relationship of age to the effects of conjugated estrogens and medroxyprogesterone combination have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have certain unwanted effects (eg, breast cancer, stroke, or dementia), which may require caution in patients receiving this medi..
