Generic name: Procainamide hydrochloride
Dosage form: capsules
Drug class:Group I antiarrhythmics
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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The prolonged administration of Procainamide often leads to the development of a positive anti-nuclear antibody (ANA) test, with or without symptoms of lupus erythematosus-like syndrome. If a positive ANA titer develops, the benefits versus risks of continued Procainamide therapy should be assessed.
Procainamide Description
Procainamide hydrochloride, a Group 1A cardiac antiarrhythmic drug, is p-amino-N-[2-(diethylamino)ethyl]-benzamide monohydrochloride. It differs from procaine which is the p-aminobenzoyl ester of 2-(diethylamino)-ethanol. Procainamide as the free base has a PKa of 9.23; the monohydrochloride is very soluble in water. Its structural formula is:
