Dosage form: injection, solution
Drug class:Progestins
Medically reviewed by Drugs.com. Last updated on Mar 1, 2021.
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Progesterone Injection Description
Progesterone Injection, a progestin, is a sterile solution of progesterone in a suitable vegetable oil available for intramuscular use.
Progesterone occurs as a white or creamy white, crystalline powder. It is odorless and is stable in air. Practically insoluble in water, it is soluble in alcohol, acetone, and dioxane and sparingly soluble in vegetable oils.
It has the following structural formula:
C21H30O2 M.W. 314.47
Pregn-4-ene-3, 20-dione
Each mL contains: Progesterone 50 mg, Benzyl Alcohol 10% as preservative in Sesame Oil q.s.
Progesterone Injection - Clinical Pharmacology
Transforms proliferative endometrium into secretory endometrium.
Inhibits (at the usual dose range) the secretion of pituitary gonadotropins, which in turn prevents follicular maturation and ovulation.
Pharmacokinetics and Metabolism:
Absorption: After intramuscular administration of 10 mg of progesterone in oil, maximum plasma concentrations (geometric mean of 7 ng/mL) were reached within approximately 8 hours after injection and plasma concentrations remained above...
