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Acetaminophen, dextromethorphan, doxylamine, and phenylephrine
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Acetaminophen, dextromethorphan, doxylamine, and phenylephrine

Generic name: acetaminophen, dextromethorphan, doxylamine, and phenylephrine [ ah-EET-a-MIN-oh-fen, DEX-troe-me-THOR-fan, dox-IL-a-meen, and-FEN-il-EFF-rin ]
Brand names: Alka-Seltzer Plus Night-Time Cold, Delsym Adult Night Time Multi-Symptom, Mucinex Fast-Max Night Time Cold & Flu, NyQuil Severe Cold & Flu, Tylenol Cold Multi-Symptom Nighttime, ... show all 10 brands
Dosage forms: oral capsule (325 mg-10 mg-6.25 mg-5 mg); oral liquid (325 mg-10 mg-6.25 mg-5 mg/15 mL; 650 mg-20 mg-12.5 mg-10 mg/30 mL); oral tablet (325 mg-10 mg-6.25 mg-5 mg); oral tablet, effervescent (250 mg-10 mg-6.25 mg-5 mg)
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com on Sep 13, 2021. Written by Cerner Multum.

What is acetaminophen, dextromethorphan, doxylamine, and phenylephrine?

Acetaminophen is a pain reliever and fever reducer.

Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing.

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, dextromethorphan, doxylamine, and phenylephrine is a combination medicine used to treat headache, fever, body aches, cough, runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.

acetaminophen, dextromethorphan, doxylamine, and phenylephrine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, dextromethorphan, doxylamine, and phenylephrine may also be used for purposes not listed in this medication guide.