Program 6 Month Injectable

Generic name: lufenuron
Dosage form: FOR ANIMAL USE ONLY

6 Month Injectable for Cats

The six-month injection that controls flea populations in cats.

Caution

U.S. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

PROGRAM® (lufenuron) 6 Month Injectable for Cats is available in two syringe sizes for subcutaneous administration to cats and kittens according to their weight (See Dosage). Each preloaded syringe is formulated to provide 4.54 mg/pound (10 mg/kg) body weight of lufenuron. The active ingredient of Program 6 Month Injectable for Cats is lufenuron, a benzoylphenyl-urea derivative with the following chemical composition: N-[2,5-dichloro-4-(1,1,2,3,3,3,-hexafluoropropoxy)-phenylaminocarbonyl]-2,6-difluorobenzamide. Benzoylphenyl-urea compounds, including lufenuron, are classified as insect development inhibitors (IDIs).

Mode of Action

Lufenuron, the active ingredient of Program 6 Month Injectable for Cats, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Lufenuron’s mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron has no effect on adult fleas.

After biting a lufenuron-treated cat, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron prevents flea eggs from hatching and developing into adults and thus controls flea populations by breaking the life cycle. (See Efficacy.)

Indications

Program 6 Month Injectable for Cats is indicated for use in cats, six weeks of age and older, for the control of flea populations.

Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of insecticides may be necessary for adequate control of adult fleas.

Warning

Do not use in dogs. A severe local reaction may occur in dogs that is not seen in cats.

Precautions

The safety of Program 6 Month Injectable for Cats in reproducing animals has not been established.

Program 6 Month Injectable for Cats breaks the flea life cycle by inhibiting egg development. However, pre-existing flea populations may continue to develop and emerge after treatment with Program 6 Month Injectable for Cats. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. Therefore, noticeable control may not be observed until several weeks after dosing when a pre-existing infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. Insecticides may be used concurrently depending on the severity of the infestation.

Efficacy

Laboratory and clinical trials have shown that Program 6 Month Injectable for Cats is a safe, effective and convenient...