Propranolol and hydrochlorothiazide (Oral)
Medically reviewed by Drugs.com. Last updated on Feb 28, 2022.
Following abrupt cessation of therapy with propranolol, exacerbations of angina pectoris and, in some cases, myocardial infarction have been reported. Even in the absence of overt angina pectoris, when discontinuing therapy, propranolol should not be withdrawn abruptly, and patients should be cautioned against interruption of therapy without the physician's advice .
Commonly used brand name(s)
In the U.S.
- Inderide
Available Dosage Forms:
- Tablet
Therapeutic Class: Beta-Adrenergic Blocker, Nonselective/Thiazide Combination
Pharmacologic Class: Propranolol
Chemical Class: Thiazide
Uses for propranolol and hydrochlorothiazide
Propranolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Propranolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.
Hydrochlorothiazide is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.
Propranolol and hydrochlorothiazide is available only with your doctor's prescription.
Before using propranolol and hydrochlorothiazide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For propranolol and hydrochlorothiazide, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to propranolol and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of propranolol and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propranolol and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propranolol and hydrochlorothiazide combination.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential..
