Prothrombin complex
Generic name: prothrombin complex [ pro-THROM-bin-KOM-plex ]
Brand name: Kcentra
Dosage form: intravenous powder for injection (-)
Drug class:Anticoagulant reversal agents
What is prothrombin complex?
Prothrombin complex is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure.
Prothrombin complex may also be used for purposes not listed in this medication guide.
Warnings
Tell your doctor if you have ever had a heart attack, stroke, TIA or "mini-stroke", chest pain, severe circulation problems, or a blood clot (especially within the past 3 months).
While using prothrombin complex, tell your caregivers right away if you have signs of a blood clot: sudden numbness or weakness, problems with vision or speech, chest pain, cough, wheezing, rapid breathing, swelling or pain in your arms, legs, or stomach.
This medicine is for use in people who use blood thinners such as warfarin. After you are treated with prothrombin complex, do not start using your blood thinner again until your doctor tells you to.
Before taking this medicine
You should not be treated with this medicine if you have:
low levels of platelets in your blood after using heparin;
excessive blood-clotting caused by a condition called disseminated intravascular coagulation; or
a history of severe allergic reaction to prothrombin complex, Protein C or Protein S, Antithrombin III, heparin, human albumin, or Factors II, VII, IX, X.
If possible before you receive prothrombin complex, tell your caregivers if you have ever had:
a stroke, including TIA (transient ischemic attack) or "mini-stroke";
a heart attack;
disseminated intravascular coagulation;
severe circulation problems;
chest pain (angina); or
if you have had a blood-clot within the last 3 months.
Tell your doctor if you are pregnant or breastfeeding.
Prothrombin complex is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.
How is prothrombin complex given?
Prothrombin complex is giv...
