Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine

Generic name: acetaminophen, dextromethorphan, guaifenesin, and phenylephrine [ a-SEET-oh-MIN-oh-fen, DEX-troe-me-THOR-fan, gwye-FEN-e-sin, FEN-il-EFF-rin ]
Brand names: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, ... show all 46 brands Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Tylenol Cold Multi-Symptom Severe Daytime, Non-Pseudo Cold Relief, Phenflu DM, Sudafed PE Cold and Cough, Cold and Cough PE, Cold Head Congestion Severe Daytime, Cold Multi-Symptom Severe Daytime Cool Ice, Tylenol Cold and Flu Severe, Mucinex Children's Multi-Symptom Cold and Fever, Mucinex Fast-Max Cold, Flu and Sore Throat, Mucinex Fast-Max Severe Congestion and Cold, Mucinex Children's Cold, Cough and Sore Throat, DayQuil Severe Cold and Flu, Adult Cold, Flu and Sore Throat, Cold and Flu Severe, Mucinex Sinus-Max Severe Congestion Relief, Sudafed PE Pressure+Pain+Cold, Delsym Cough + Cold Daytime, Severe Day Time Cold and Flu, Mucinex Fast-Max Cold and Flu, Mucinex Sinus-Max Pressure, Pain and Cough, Mucinex Children's Multi-Symptom Cough, Cold and Fever, Mucinex Fast-Max Cold, Flu and Sore Throat Clear and Cool, Severe Cold Maximum Strength, Mucus Relief Cold, Flu and Sore Throat, Mucinex Fast-Max Cold and Flu Arctic Burst, Mucinex Children Multi-Symptom Cold Sore throat Very Berry, Mucinex Children's Multisymptom Cold, Flu and Sore Throat, Mucinex Junior Cold and Flu, Mucinex FreeFrom Cold and Flu Daytime
Dosage forms: oral capsule (325 mg-10 mg-200 mg-5 mg); oral liquid (325 mg-10 mg-200 mg-5 mg/10 mL; 325 mg-10 mg-200 mg-5 mg/15 mL; 650 mg-20 mg-400 mg-10 mg/20 mL); oral powder for reconstitution (650 mg-20 mg-400 mg-10 mg); oral tablet (325 mg-10 mg-100 mg-5 mg; 325 mg-10 mg-200 mg-5 mg)
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com on Nov 29, 2021. Written by Cerner Multum.

What is acetaminophen, dextromethorphan, guaifenesin, and phenylephrine?

Acetaminophen is a pain reliever and fever reducer.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine is a combination medicin