Quinaretic
Generic name:quinapril hydrochloride and hydrochlorothiazide
Dosage form: tablets
Drug class:ACE inhibitors with thiazides
Medically reviewed by Drugs.com. Last updated on May 23, 2022.
Quinaretic®
(Quinapril Hydrochloride and Hydrochlorothiazide Tablets) 8263-07
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USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, Quinaretic should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.
The Quinaretic brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Quinaretic Description
Quinaretic is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide.
Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5.HCl and its structural formula is:
M.W. = 474.98
Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents.
Hydrochlorothiazide is chemically described as: 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:
