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Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine
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Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine

Generic name: acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine [ a-SEET-a-MIN-oh-fen, DEX-troe-me-THOR-fan, gwye-FEN-e-sin, SOO-doe-ee-FED-rin ]
Brand names: Duraflu, Robitussin Cold Cough and Flu, Theraflu Max-D Severe Cold & Flu, Sudafed Cold and Cough Liquicaps, Theraflu Chest and Cough, ... show all 12 brands
Dosage forms: oral capsule (250 mg-10 mg-100 mg-30 mg); oral powder for reconstitution (1000 mg-30 mg-400 mg-60 mg); oral tablet (250 mg-10 mg-100 mg-30 mg; 325 mg-15 mg-200 mg-30 mg; 325 mg-20 mg-200 mg-60 mg; 500 mg-20 mg-200 mg-60 mg)
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com on Nov 1, 2021. Written by Cerner Multum.

What is acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine?

Acetaminophen is a pain reliever and fever reducer.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine is a combination medicine used to treat headache, fever, body aches, cough, chest congestion, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine may also be used for purposes not listed in this medication guide.

Warnings

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-