Relugolix
Generic name: relugolix
Brand name: Orgovyx
Dosage form: oral tablet
Drug class:Gonadotropin-releasing hormone antagonists
What is relugolix?
Relugolix is a prescription medicine used to treat adults with advanced prostate cancer, which comes as a tablet.
Relugolix belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) receptor antagonists. In 2020, it was the first oral drug in its class to be approved by the US Food and Drug Administration (FDA) for prostate cancer patients.
Most prostate cancers need an androgen or sex hormone called testosterone to help them grow. Relugloix works by binding to GnRH receptors in your pituitary gland, which reduces how much luteinizing hormone (LH) and follicle-stimulating hormone (FSH) they release. This deceases the amount of testosterone produced and helps to slow or stop the spread of the cancer cells that rely on this hormone for their growth.
What is relugloix used for?
Relugolix is used in adults for the treatment of advanced prostate cancer.
It is not known if relugolix is safe or effective in females.
It is not known if relugolix is safe or effective in children.
What should I tell my doctor before taking relugolix?
Before taking relugolix, tell your healthcare provider about all of your medical conditions, including if you:
- have any heart problems, including a condition called long QT syndrome.
How should I take relugolix?
- Take relugolix exactly as your healthcare provider tells you.
- Take 3 relugolix tablets on your first day of treatment. After that, take 1 relugolix tablet each day.
- Take relugolix at about the same time each day.
- Take relugolix with or without food.
- Swallow relugolix tablets whole. Do not crush or chew tablets.
- Your healthcare provider may change your dose if needed.
- Do not change your dose or stop taking relugolix without talking with your healthcare provider first.
What happens if I miss a dose?
If you miss a dose of relugolix, take it as soon as you remember. If the dose was missed by more than 12 hours, the missed dose should not be taken. Take your next dose at your regular time the next day.
Dosing information
The recommended dose of relugolix is a loading dose of 360 mg on the first day of treatment followed by 120 mg taken orally once daily, at approximately the same time each day.
Relugolix can be taken with or without food. The tablets must be swallowed whole and not crushed or chewed.
See full prescribing information for further details about relugolix dosing.
