Relugolix, estradiol, and norethindrone (Oral)
Medically reviewed by Drugs.com. Last updated on Mar 25, 2022.
Estrogen and progestin combination products, including relugolix/estradiol/norethindrone acetate, increase the risk of thrombotic or thromboembolic disorders including pulmonary embolism (PE), deep vein thrombosis (DVT), stroke and myocardial infarction (MI), especially in women at increased risk for these events. Relugolix/estradiol/norethindrone acetate is contraindicated in women with current or a history of thrombotic or thromboembolic disorders and in women at increased risk for these events, including women over 35 years of age who smoke or women with uncontrolled hypertension .
Commonly used brand name(s)
In the U.S.
- Myfembree
Available Dosage Forms:
- Tablet
Therapeutic Class: Endocrine-Metabolic Agent
Pharmacologic Class: Luteinizing Hormone Releasing Hormone Antagonist
Uses for relugolix, estradiol, and norethindrone
Relugolix, estradiol, and norethindrone combination is used to manage heavy menstrual bleeding caused by uterine leiomyomas (fibroids) in premenopausal women.
Relugolix, estradiol, and norethindrone is available only with your doctor's prescription.
Before using relugolix, estradiol, and norethindrone
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For relugolix, estradiol, and norethindrone, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to relugolix, estradiol, and norethindrone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of relugolix, estradiol, and norethindrone combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
No information is available on the relationship of age to the effects of relugolix, estradiol, and norethindrone combination in geriatric patients.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking relugolix, estradiol, and norethindrone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using relugolix, estradiol, and norethindrone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicine..
