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Reme Hist DM
  • Professionals
  • FDA PI

Reme Hist DM

Generic name:pyrilamine maleate, phenylephrine hydrochloride, dextromethorphan hydrobromide
Dosage form: liquid
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

DESCRIPTION:

Reme Hist DM is a sugar free, alcohol free, dye free, clear and colorless liquid with a grape flavor. Each 5mL (1 teaspoonful) contains:
Pyrilamine Maleate 12.5 mg
Phenylephrine HCl 7.5 mg
Dextromethorphan HBr 15 mg

Pyrilamine Maleate is an antihistamine that occurs as a white crystalline powder, usually having a faint odor. It is very soluble in water, freely soluble in alcohol and chloroform, and slightly soluble in ether and benzene. The chemical name is 1, 2-ethanediamine, N-[(4 methoxyphenyl) methyl]-N: N-dimethyl-N-2- pyridinyl-, (Z)-2-butenedioate(1:1). Its structural formula is as follows:

Dextromethorphan Hydrobromide is an antitussive which is a salt of the methyl ether of dextrorotatory isomer of levorphanol, a narcotic analgesic. Chemically, it is 3-methoxy-17-methyl-9_, 13_, 14_morphinan hydrobromide:

Phenylephrine Hydrochloride is a decongestant that occurs as white or practically white, odorless crystals, having a bitter taste. It is freely soluble in water and in alcohol. It is affected by light. The chemical name is benzenemethanol, 3-hydroxy-alpha[(methylamino)methyl]-,hydrochloride. Its structural formula is as follows:

Inactive Ingredients: The inactive ingredients are Citric acid, Glycerin, Grape Flavor, Propylene Glycol, Magnasweet, Purified Water, Saccharin Sodium, Sodium Benzoate, Sorbitol and Xanthan Gum.

CLINICAL PHARMACOLOGY:

Pyrilamine Maleate: Pyrilamine is an antihistamine belonging to the ethylenediamine class. Pyrilamine is a highly effective H1 blocker which possesses local anesthetic activity. Pyrilamine antagonizes most of the smooth muscle stimulating actions of histamine