Renese-R
Generic name: polythiazide and reserpine
Dosage form: Tablets
Drug class:Antiadrenergic agents (peripheral) with thiazides
Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.
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This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static, but must be reevaluated as conditions in each patient warrant.
Renese-R Description
RENESE®-R tablets combine polythiazide and reserpine, two antihypertensive agents with complementary properties. Each blue, scored tablet of Renese-R provides:
Renese (polythiazide). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.0 mg
Reserpine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . .0.25 mg
RENESE (polythiazide) is a member of the benzothiazide (thiazide) family of diuretic/antihypertensive agents. It is designated chemically as 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-[[2,2,2-trifluoroethyl)thio]methyl]-,1,1-dioxide with a molecular formula of C11H13ClF3N3O4S3 and a molecular weight of 439.87.
Polythiazide is a white crystalline substance insoluble in water, but readily soluble in alkaline solution, and has the following structural formula:
Reserpine, one of the alkaloids of Rauwolfia serpentina, has the following structural formula:
Reserpine – which is administered orally, is insoluble in water, very slightly soluble in ether, l g in about 1800 mL alcohol and about 6 mL chloroform, slightly soluble in benzene, freely soluble in acetic acid.
It has a molecular weight of 608.69 and its mole...
