Renografin-60
Generic name:diatrizoate meglumine and diatrizoate sodium
Dosage form: Injection
Drug class:Ionic iodinated contrast media
Medically reviewed by Drugs.com. Last updated on Sep 21, 2021.
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The Renografin-60 brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Renografin-60 Description
Renografin-60 (Diatrizoate Meglumine and Diatrizoate Sodium Injection USP) is a radiopaque contrast agent supplied as a sterile, aqueous solution. Each mL provides 520 mg diatrizoate meglumine and 80 mg diatrizoate sodium; at manufacture, 3.2 mg sodium citrate and 0.4 mg edetate disodium are added per mL. The pH has been adjusted between 6.0 and 7.7 with sodium hydroxide and diatrizoic acid. Each mL of solution also contains approximately 3.76 mg (0.16 mEq) sodium and 292.5 mg organically bound iodine. At the time of manufacture, the air in the container is replaced by nitrogen.
Renografin-60 - Clinical Pharmacology
Following intravascular injection, Renografin-60 is rapidly transported through the bloodstream to the kidneys and is excreted unchanged in the urine by glomerular filtration. When urinary tract obstruction is severe enough to block glomerular filtration, the agent appears to be excreted by the tubular epithelium.
Certain applications of the contrast agent make use of the natural physiologic mechanism of excretion. Thus, the intravenous injection of the agent permits visualization of the kidneys and urinary passages.
Renal accumulation is sufficiently rapid that the period of maximal opacification of the renal passages may begin as early as five minutes after injection. In infants and small children excretion takes place somewhat more promptly than in adults, so that maximal opacification occurs more rapidly and is less sustained. The normal kidney eliminates the contrast medium almost immediately. In nephropathic conditions, particularly when excretory capacity has been altered, the rate of excretion varies unpredictably, and opacification may be delayed for 30 minutes or more after injection; with severe impairment opacification may not occur. Generally, however, the medium is concentrated in sufficient amounts and promptly e...
