Rimexolone

Class: Corticosteroids
ATC Class: S01BA13
VA Class: OP300
Chemical Name: 11β-Hydroxy-16α, 17α-dimethyl-17-propionylandrosta-1,4-diene-3-one
Molecular Formula: C₂₄H₃₄O₃
CAS Number: 49697-38-3
Brands: Vexol

Medically reviewed by Drugs.com on May 23, 2022. Written by ASHP.

Introduction

A synthetic nonfluorinated corticosteroid.

Uses for Rimexolone

Postoperative Ocular Inflammation

Treatment of postoperative ocular inflammation following ocular surgery (e.g., cataract extraction).

Anterior Uveitis

Treatment of anterior uveitis.

Rimexolone Dosage and Administration

Administration

Ophthalmic Administration

Apply topically to the eye(s) as an ophthalmic suspension.

Avoid contamination of preparation container.

Shake suspension well before using.

Do not administer rimexolone by injection.

Dosage

Adults

Postoperative Ocular Inflammation

Ophthalmic

Instill 1 or 2 drops of 1% suspension into the conjunctival sac of the affected eye(s) 4 times daily beginning 24 hours after surgery and continuing for 2 weeks.

Anterior Uveitis

Ophthalmic

Instill 1 or 2 drops of 1% suspension into the conjunctival sac of the affected eye(s) every hour while awake for 7 days, then 1 drop every 2 hours while awake for an additional 7 days.

Duration of subsequent therapy depends on severity of the disease and response to therapy.

Gradually taper the dosage when the drug is discontinued to avoid exacerbation of the disease.

Special Populations

No special population dosage recommendations at this time.

Cautions for Rimexolone

Contraindications

• Known or suspected hypersensitivity to rimexolone or any ingredient in the formulation.

• Viral diseases of the cornea and conjunctiva (e.g., epithelial herpes simplex keratitis [dendritic keratitis], vaccinia, varicella).

• Mycobacterial infection of the eye.

• Fungal disease of ocular structures.

• Acute purulent untreated infections.

Warnings/Precautions

Warnings

Ocular Effects

Risk of ocular hypertension or glaucoma (with damage to optic nerve), defects in visual acuity and fields of vision, and posterior subcapsular cataract formation with prolonged use of corticosteroids. Use with caution in glaucoma because intraocular pressure (IOP) may increase.

In conditions causing thinning of the cornea or sclera, perforations reported with us...