Ravicti Oral Liquid

Generic name:glycerol phenylbutyrate
Dosage form: oral liquid
Drug class:Urea cycle disorder agents

Medically reviewed by Drugs.com. Last updated on Sep 1, 2021.

Indications and Usage for Ravicti Oral Liquid

RAVICTI is indicated for use as a nitrogen-binding agent for chronic management of patients with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone. RAVICTI must be used with dietary protein restriction and, in some cases, dietary supplements (e.g., essential amino acids, arginine, citrulline, protein-free calorie supplements).

Limitations of Use:

• RAVICTI is not indicated for the treatment of acute hyperammonemia in patients with UCDs because more rapidly acting interventions are essential to reduce plasma ammonia levels.
• The safety and efficacy of RAVICTI for the treatment of N-acetylglutamate synthase (NAGS) deficiency has not been established.

Ravicti Oral Liquid Dosage and Administration

Important Administration Instructions

RAVICTI should be prescribed by a physician experienced in the management of UCDs.

• Instruct patients to take RAVICTI with food or formula and to administer directly into the mouth via oral syringe.
• Instruct patients to use the RAVICTI bottle and oral syringe as follows:
  • Use a new reclosable bottle cap adapter with each new bottle that is opened.
  • Open the RAVICTI bottle and twist on the new reclosable bottle cap adapter.
  • Use a new and dry oral syringe to withdraw each prescribed dose of RAVICTI.
  • Discard the oral syringe after each dose.
  • Tightly close the tethered tab on the reclosable bottle cap adapter after each use.
  • Do not rinse the reclosable bottle cap adapter.
  • Discard bottle and an...