Rosiglitazone and glimepiride (Oral)
Medically reviewed by Drugs.com. Last updated on Jun 7, 2022.
Thiazolidinediones, including rosiglitazone, may cause or worsen congestive heart failure and are not recommended in patients with symptomatic heart failure. The initiation of glimepiride/rosiglitazone maleate is contraindicated in patients with NYHA Class III or IV heart failure. Monitor patients for signs and symptoms of heart failure after initiation or dose increases and consider dose reduction or discontinuation if symptoms develop .
Commonly used brand name(s)
In the U.S.
- Avandaryl
Chemical Class: 2nd Generation Sulfonylurea
Uses for rosiglitazone and glimepiride
Rosiglitazone and glimepiride combination is used to treat a type of diabetes mellitus called type 2 diabetes. It is used together with a proper diet and exercise to help control blood sugar levels.
Rosiglitazone helps your body use insulin better. Glimepiride stimulates the release of insulin from the pancreas which will help your body turn food into energy.
Rosiglitazone and glimepiride is only available with your doctor's prescription.
Before using rosiglitazone and glimepiride
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rosiglitazone and glimepiride, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to rosiglitazone and glimepiride or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of rosiglitazone and glimepiride combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rosiglitazone and glimepiride combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving rosiglitazone and glimepiride combination.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rosiglitazone and glimepiride, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using rosiglitazone and glimepiride with any of the following medicines is usually not recommended, but may be requir..
