Rosiglitazone and metformin (Oral)
Medically reviewed by Drugs.com. Last updated on Feb 23, 2022.
Thiazolidinediones may cause or worsen congestive heart failure in some patients, Use in patients with established NYHA class III or IV heart failure is contraindicated and use in patients with symptomatic heart failure is not recommended. Monitor patients for signs and symptoms of heart failure after initiation or dose increases. If heart failure occurs, consider reducing the dose or discontinuing rosiglitazone therapy and manage patient according to current standards of care. Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms. The risk of lactic acidosis is increased with renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors, such as topiramate), age 65 years old or greater, having a radiologic study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment. If lactic acidosis is suspected, immediately discontinue use and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended .
Commonly used brand name(s)
In the U.S.
- Avandamet
Available Dosage Forms:
- Tablet
Therapeutic Class: Hypoglycemic
Chemical Class: Metformin
Uses for rosiglitazone and metformin
Rosiglitazone and metformin combination is used to treat a type of diabetes mellitus called type 2 diabetes. It is used together with a proper diet and exercise to help control blood sugar levels.
Rosiglitazone helps your body use insulin better. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better.
Rosiglitazone and metformin is available only with your doctor's prescription.
Before using rosiglitazone and metformin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rosiglitazone and metformin, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to rosiglitazone and metformin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of rosiglitazone and metformin combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rosiglitazone and metformin combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving rosiglitazone and metformin combination.
Breastfeeding
There are no adequate studies in women fo..
