Rozlytrek
Generic name:entrectinib [ en-TREK-ti-nib ]
Drug class:Multikinase inhibitors
What is Rozlytrek?
Rozlytrek is used in adults to treat non-small cell lung cancer that has spread to other parts of the body (metastatic).
Rozlytrek is also used in adults and children at least 12 years old who have solid tumors that have spread or cannot be safely removed with surgery, or when other treatments have failed or are not safe options.
Rozlytrek is used only if your cancer has a specific abnormal gene. Your doctor will test you for this gene.
Warnings
Rozlytrek may cause new or worsened symptoms of congestive heart failure. Call your doctor at once if you have swelling in your lower legs, rapid weight gain, cough, wheezing, shortness of breath, or trouble breathing while lying down.
Before taking this medicine
To make sure Rozlytrek is safe for you, tell your doctor if you have ever had:
gout;
heart problems;
long QT syndrome (in you or a family member);
liver or kidney disease;
a nervous system disorder; or
problems with your eyes or vision.
You may need to have a negative pregnancy test before starting this treatment.
Entrectinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
If you are a woman, do not use Rozlytrek if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 weeks after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Rozlytrek.
Do not breastfeed while using this medicine, and for at least 7 days after your last dose.
How should I take Rozlytrek?
Use Rozlytrek exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take Rozlytrek with or without food.
Swallow the capsule whole and do not crush, chew, break, or open it.
If you vomit shortly after taking Rozlytrek, take another dose.
Store at room temperature away from moisture and heat.
Do not change your dose or stop taking Rozlytrek without your doctor's advice.
Dosing information
Usual Adult Dose for Non-Small Cell Lung Cancer:
600 mg orally once a day until disease progression or unacceptable toxicity
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