Rucaparib
Generic name: rucaparib [ roo-KAP-a-rib ]
Brand name: Rubraca
Dosage form: oral tablet (200 mg; 250 mg; 300 mg)
Drug class:PARP inhibitors
What is rucaparib?
Rucaparib is used to treat ovarian cancer, fallopian tube cancer, or primary peritoneal cancer (cancer of the membrane lining the organs inside your abdomen). Rucaparib is sometimes used for these conditions only if your cancer has a specific genetic marker (an abnormal "BRCA" gene). Your doctor will test you for this gene.
Rucaparib is also used to treat prostate cancer with an abnormal BRCA gene. Rucaparib is given for this condition when the cancer has spread to other parts of the body and surgery or other cancer treatments did not work or have stopped working.
Rucaparib was approved for prostate cancer by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to rucaparib, but further studies are needed.
Rucaparib may also be used for purposes not listed in this medication guide.
Warnings
Rucaparib can cause leukemia or serious bone marrow problems. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, shortness of breath, or signs of infection (fever, feeling weak or tired, weight loss).
Before taking this medicine
Using rucaparib may increase your risk of developing serious bone marrow problems or other types of cancer, such as leukemia. Ask your doctor about your specific risk.
Rucaparib can harm an unborn baby if the mother or the father is using rucaparib.
If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use rucaparib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using rucaparib.
You should not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
How should I take rucaparib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dos...
