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Samsca
  • Treatments
  • Euvolemic Hyponatremia

Samsca

Generic name:tolvaptantol-VAP-tan ]
Drug class:Vasopressin antagonists

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 13, 2021.

What is Samsca?

Samsca is an oral tablet that reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention.

Samsca is used to treat hyponatremia (low levels of sodium in your blood) in people with heart failure, and certain hormonal imbalances.

Samsca improves urine flow without causing the body to lose too much sodium as you urinate.

This medication guide provides information about the Samsca brand of tolvaptan. Jynarque is another brand of tolvaptan that is not covered in this medication guide.

Warnings

You should not use Samsca if you are dehydrated or unable to urinate, or if you can't tell when you are thirsty.

You will need to be in a hospital under observation any time you start or restart treatment.

If you have polycystic kidney disease, do not use Samsca. You should be prescribed another brand of tolvaptan (Jynarque) through a special program that ensures laboratory monitoring of your liver.

Samsca is given to treat low levels of sodium in your blood, but can be dangerous if this condition is reversed too quickly. Tell your caregivers at once if you have problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, confusion, or seizure.

Tolvaptan can cause serious or fatal liver problems. Call your doctor right away if you don't feel well and you have right-sided upper stomach pain, vomiting, loss of appetite, or yellowing of your skin or eyes.

You will need frequent medical tests before and during treatment with Samsca.

Tell your d...