Saphris

Generic name:asenapine (sublingual) [ a-SEN-a-peen ]
Drug class:Atypical antipsychotics

Medically reviewed by Sophia Entringer, PharmD. Last updated on Apr 11, 2022.

What is Saphris?

Saphris is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Saphris sublingual tablets are used to treat schizophrenia in adults, and bipolar I disorder in adults and children who are at least 10 years old.

Saphris may used alone. In adults it may be used in conjuction with lithium or valproate.

Warnings

You should not use Saphris if you are allergic to asenapine, or if you have severe liver disease.

Saphris is not approved for use in older adults with dementia-related psychosis.

Saphris can cause serious neurologic problems. Stop taking this medicine and call your doctor at once if you have: very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling light-headed, tremors, twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Before taking this medicine

You should not use Saphris if you are allergic to asenapine, or if you have:

• severe liver disease.

Asenapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

To make sure Saphris is safe for you, tell your doctor if you have:

• heart problems;

• high blood pressure;

• a heart attack or stroke;

• diabetes (asenapine may raise your blood sugar);

• a s...