Scandonest L
Generic name:mepivacaine hydrochloride and levonordefrin
Dosage form: injection, solution
Drug class:Local injectable anesthetics
Medically reviewed by Drugs.com. Last updated on Feb 1, 2022.
Rx Only
THESE SOLUTIONS ARE INTENDED FOR DENTAL USE ONLY.
DESCRIPTION:
Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula:
It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.
Levonordefrin, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solution, is (-)-
-(1-Aminoethyl)-3, 4-dihydroxybenzyl alcohol with the following structural formula:
It is a white or buff-colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water;
DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.
SCANDONEST® 3% (30 mg/mL) Plain (mepivacaine hydrochloride injection 3% (30 mg/mL)) and SCANDONEST® 2% (20 mg/mL) L (mepivacaine hydrochloride 2% (20 mg/mL) with levonordefrin 1:20,000 injection are sterile solutions for injection.
COMPOSITION:
| Each mL contains: | 2% | 3% |
| Mepivacaine Hydrochloride | 20 mg | 30 mg |
| Levonordefrin | 0.05 mg | - |
| Sodium Chloride | 4 mg | 6 mg |
| Potassium metabisulfite | 1.2 mg | - |
| Edetate disodium | 0.25 mg | - |
| Sodium Hydroxide q.s. ad pH; Hydrochloric Acid | 0.5 mg | - |
| Water for Injection q.s. ad. | 1 mL | 1 mL |
The pH of the 2% cartridge solution is adjusted between 3.3 and 5.5 with NaOH. | ||
| The pH of the 3% cartridge solution is adjusted between 4.5 and 6.8 with NaOH. |
CLINICAL PHARMACOLOGY:
SCANDONEST® stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia.
SCANDONEST® is rapidly metabolized, with only a small percentage of the anesthetic (5 to 10 percent) being excreted unchanged in the urine. SCANDONEST® because of its amide structure, is not detoxified by the circulating plasma esteras...
