SE 10-5 SS Cream
Generic name:sodium sulfacetamide, sulfur
Dosage form: cream
Drug class:Topical antibiotics
Medically reviewed by Drugs.com. Last updated on Jul 22, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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The SE 10-5 SS brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
DESCRIPTION:
Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically sodium sulfacetamide is N-[(4-aminophenyl) sulfonyl]-acetamide, monosodium salt, monohydrate. The structural formula is:
Each gram of SE 10-5 SS (sodium sulfacetamide USP 10% and sulfur USP 5%) Cream contains: Active: Sodium Sulfacetamide 10% (100 mg) and Sulfur 5% (50 mg). Inactive: Benzyl Alcohol, Emulsifying Wax, Fragrance, Hamaelis virginiana (Witch Hazel) Distillate, Kaolin, Propanediol, Purified Water, Quillaja (Quillaia) saponaria Extract, Silicon Dioxide, Sodium Hydroxide, and Sodium Thiosulfate.
CLINICAL PHARMACOLOGY:
The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.
INDICATIONS:
SE 10-5 SS (sodium sulfacetamide 10% and sulfur 5%) Cream is indicated in the topical c...
