Atenolol and Chlorthalidone Tablets

Dosage form: tablet
Drug class:Beta blockers with thiazides

Medically reviewed by Drugs.com. Last updated on Mar 1, 2022.

Atenolol and Chlorthalidone Tablets Description

Atenolol and Chlorthalidone Tablets, USP are for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta1-selective (cardioselective) hydrophilic blocking agent (atenolol) and a monosulfonamyl diuretic (chlorthalidone).

Atenolol is Benzeneacetamide, 4-[2'-hydroxy-3'-[(1-methylethyl) amino] propoxy]-.

Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

Chlorthalidone is 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl) benzene sulfonamide:

Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.

Each Atenolol and Chlorthalidone Tablet, USP 100 mg/25 mg contains:

Atenolol, USP .....100 mg

Chlorthalidone, USP .....25 mg

Each Atenolol and Chlorthalidone Tablet, USP 50 mg/25 mg contains:

Atenolol, USP .....50 mg