Selinexor
Generic name: selinexor [ SEL-i-NEX-or ]
Brand names: Xpovio 100 mg once-weekly, Xpovio 40 mg once-weekly, Xpovio 40 mg twice-weekly, Xpovio 60 mg once-weekly, Xpovio 60 mg twice-weekly,
... show all 8 brands
Dosage form: oral tablet (20 mg; 40 mg; 50 mg; 60 mg)
Drug class:Miscellaneous antineoplastics
What is selinexor?
Selinexor is used together with bortezomib and/or dexamethasone to treat multiple myeloma in adults.
Selinexor is also used in adults to treat certain types of diffuse large B-cell lymphoma.
Selinexor is given after other medications did not work or have stopped working.
Selinexor was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to selinexor, but further studies are needed.
Selinexor may also be used for purposes not listed in this medication guide.
Warnings
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms, cough, mouth ulcers, or trouble breathing,
Selinexor can also cause low platelet counts in your blood. Tell your doctor right away if you have unusual bruising or bleeding.
Before taking this medicine
Tell your doctor if you have ever had:
cataracts;
bleeding problems; or
an active or recent infection.
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using selinexor should use effective birth control to prevent pregnancy. Selinexor can harm an unborn baby if the mother or father is using this medicine.
Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using selinexor.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selinexor can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Not approved for use by anyone younger than 18 years old.
How should I take selinexor?
Your doctor will perform tests to make sure selinexor is the right treatment for you.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Yo
