Atezolizumab
Generic name: atezolizumab
Brand name: Tecentriq
Dosage form: intravenous (infusion) injection
Drug class:Anti-PD-1 monoclonal antibodies
What is atezolizumab?
Atezolizumab is a type of immunotherapy drug that helps the body's immune system to track down and fight cancer. It is a monoclonal antibody that works by blocking a protein called programmed death-ligand 1 (PD-L1). It is part of a group of drugs called immune checkpoint inhibitors, which help to extend the amount of time a person can live with cancer or life without their cancer getting worse.
Atezolizumab. was first approved by the US Food and Drug Administration (FDA) in 2016.
What is atezolizumab used for?
Atezolizumab is a prescription medicine used to treat adults with:
- a type of bladder and urinary tract cancer called urothelial carcinoma. Atezolizumab may be used when your bladder cancer has spread or cannot be removed by surgery, and if you have any one of the following conditions:
- you are not able to take chemotherapy that contains a medicine called cisplatin, and your cancer tests positive for "PD-L1", or
- you are not able to take chemotherapy that contains any platinum regardless of "PD-L1" status.
- a type of lung cancer called non-small cell lung cancer (NSCLC).
- Atezolizumab may be used alone as a treatment for your lung cancer:
- to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery and you have received platinum-based chemotherapy, and
- you have stage 2 to stage 3A NSCLC (talk to your healthcare provider about what these stages mean), and
- your cancer tests positive for "PD-L1".
- Atezolizumab may be used alone as your first treatment when your lung cancer:
- has spread or grown, and
- your cancer tests positive for "high PD-L1", and
- your tumor does not have an abnormal "EGFR" or "ALK" gene.
- Atezolizumab may be used with the medicines bevacizumab, paclitaxel, and carboplatin as your first treatment when your lung cancer:
- has spread or grown, and
- is a type called "non-squamous NSCLC", and
- your tumor does not have an abnormal "EGFR" or "ALK" gene.
- Atezolizumab may be used with the medicines paclitaxel protein-bound and carboplatin as your first treatment when your lung cancer:
- has spread or grown, and
- is a type called "non-squamous NSCLC", and
- your tumor does not have an abnormal "EGFR" or "ALK" gene.
- Atezolizumab may also be used alone when your lung cancer:
- has spread or grown, and
- you have tried chemotherapy that contains platinum, and it did not work or is no longer working.
- if your tumor has an abnormal "EGFR" or "ALK" gene, you should have also tried an FDA-approved therapy for tumors with these abnormal genes, and it did not work or is no longer working.
- Atezolizumab may be used alone as a treatment for your lung cancer:
- a type of lung cancer called
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