Sertaconazole

Class: Azoles
VA Class: DE102
Chemical Name: (±)-1-[2,4-Dichloro-β-[(7-chlorobenzo[b]thien-3-yl)methoxy]phenylethyl]-imidazole mononitrate
Molecular Formula: C₂₀H₁₅Cl₃N₂OSH NO₃
CAS Number: 99592-32-2
Brands: Ertaczo

Medically reviewed by Drugs.com on Jun 21, 2021. Written by ASHP.

Introduction

Antifungal; azole (imidazole derivative).

Uses for Sertaconazole

Dermatophytoses

Treatment of interdigital tinea pedis (athlete’s foot) caused by Epidermophyton floccosum, Trichophyton mentagrophytes, or T. rubrum in immunocompetent adults and children ≥12 years of age.

Topical antifungals usually effective for treatment of uncomplicated tinea pedis; an oral antifungal usually necessary for treatment of hyperkeratotic areas on the palms and soles, for chronic moccasin-type (dry-type) tinea pedis, and for treatment of tinea unguium (onychomycosis).

Treatment of tinea corporis† (ringworm of the body), tinea cruris† (jock itch), or tinea manuum† (hand ringworm) caused by E. floccosum, Microsporum (including M. canis), or Trichophyton (including T. mentagrophytes, T. rubrum, and T. schonleinii).

Topical antifungals usually effective for uncomplicated tinea corporis, tinea cruris, and tinea manuum; an oral antifungal usually necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.

Pityriasis (Tinea) Versicolor

Treatment of pityriasis (tinea) versicolor† caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).

Topical treatment usually effective; an oral antifungal (alone or in conjunction with a topical agent) may be necessary in patients who have extensive or severe infections or who fail to respond to or have frequent relapses with topical therapy.

Cutaneous Candidiasis

Treatment of superficial cutaneous candidiasis caused by Candida albicans†.

Sertaconazole Dosage and Administration

Administration

Topical Administration

Apply topically to the skin as a 2% cream.

Do not apply to the eye or administer orally or intravaginally.

Avoid contact with the nose, mouth, and other mucous membranes.

Do not use with occlusive dressings or wrappings, unless otherwise directed by clinician.

Apply a sufficient amount of cream twice daily; rub gently into affected area (e.g., between the toes) and immediately surrounding healthy skin.

Dosage

Available as sertaconazole nitrate; dosage expressed in terms of sertaconazole nitrate.

Pediatric Patients

Dermatophytoses

Tinea Pedis (Interdigital)

Children ≥12 years of age: Apply twice daily for 4 weeks.

If clinical improvement does not occur after 2 .