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Sertraline
  • Treatments
  • Depression

Sertraline

Generic name: sertraline [ SER-tra-leen ]
Brand name: Zoloft
Dosage forms: oral concentrate (20 mg/mL); oral tablet (100 mg; 25 mg; 50 mg)
Drug class:Selective serotonin reuptake inhibitors

Medically reviewed by Kaci Durbin, MD. Last updated on May 23, 2022.

What is sertraline?

Sertraline is an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). It is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD).

Sertraline is also used to treat premenstrual dysphoric disorder.

Warnings

You should not use sertraline if you also take pimozide, or if you are being treated with methylene blue injection.

Do not use sertraline if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some children and young adults have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Before taking this medicine

You should not use sertraline if you are allergic to it, or if you also take pimozide. Do not use the liquid form of this medicine if you take disulfiram (Antabuse).

Do not use sertraline within 14 days before or 14 days after using an MAO inhibitor. A dangerous drug interaction coul...