Siklos

Generic name:hydroxyurea [ hye-DROX-ee-yoo-REE-a ]
Brand names: Droxia, Hydrea, Mylocel, Siklos
Drug class:Antimetabolites

Medically reviewed by Drugs.com on Mar 14, 2022. Written by Cerner Multum.

What is Siklos?

Siklos is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck).

Siklos is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia. This medicine will not cure sickle cell anemia.

Siklos may also be used for purposes not listed in this medication guide.

Warnings

Both men and women using Siklos should use birth control to prevent pregnancy. The use of Siklos by either parent may cause birth defects.

Using Siklos may increase your risk of developing other types of cancer, such as leukemia or skin cancer. Wear protective clothing and use sunscreen when you are outdoors.

Siklos can weaken your immune system. Call your doctor at once if you have a fever, chills, body aches, extreme tiredness, shortness of breath, bruising, or unusual bleeding.

Before taking this medicine

You should not use Siklos if you are allergic to it.

Tell your doctor if you have ever had:

• kidney disease (or if you are on dialysis);

• liver disease;

• a wound or ulcer on your leg;

• HIV or AIDS (especially if you take antiviral medicine);

• high levels of uric acid in your blood; or

• treatment with an interferon, chemotherapy, or radiation.

Using Siklos may increase your risk of developing other types cancer or leukemia. Talk with your doctor about your specific risk.

Siklos can harm an unborn baby. Both men and women using this medicine should use birth control to prevent pregnancy. The use of this medicine by either parent may cause birth defects.

• If you are a woman, keep using birth control for at least 6 months after your last dose of Siklos.

• If you are a man, keep using birth control for at least 1 year after your last dose (6 months if you took Siklos).

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control because Siklos may harm the baby if a pregnancy does occur.

You should not breastfeed while you are taking Siklos.

Older adults may be more sensitive to the effects of this medicine.