Sildec PE Syrup
Generic name:chlorpheniramine maleate and phenylephrine hydrochloride
Dosage form: syrup
Drug class:Upper respiratory combinations
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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The Sildec-PE brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Sildec PE Syrup Description
CPM/PE Syrup is a sugar-free, alcohol-free, raspberry flavored syrup for oral administration for adults and pediatric patients 2 years and older.
Each teaspoonful (5 mL) contains:
Chlorpheniramine maleate ………… 4.0 mg
Phenylephrine hydrochloride ……… 12.5 mg
Inactive ingredients: Citric acid, D & C Red No. 33, flavor, glycerin, purified water, sodium benzoate, sodium citrate, sodium saccharin, and sorbitol.
Chlorpheniramine maleate is an antihistamine with the chemical name: 2-Pyridinepropanamine, y-(4-chlorophenyl)-N, N-dimethyl-,(Z)-2-butenedioate (1:1). Its chemical structure is as follows:
Phenylephrine hydrochloride is a mydriatic and a decongestant with the chemical name: (-)-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol hydrochloride. Its chemical structure is as follows:
Sildec PE Syrup - Clinical Pharmacology
Antihistaminic and decongestant actions.
Chlorpheniramine maleate possesses H1 antihistaminic activity and mild anticholinergic and sedative effects. Peak plasma concentration is reached in 5 hours. Urinary excretion is the major route of elimination. The liver is assumed to be the major site of metabolic transformation.
Phenylephrine hydrochlo.
