Sildec Syrup
Generic name:brompheniramine maleate and pseudoephedrine hydrochloride
Dosage form: syrup
Drug class:Upper respiratory combinations
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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The Sildec brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Sildec Syrup Description
Antihistamine/Decongestant for oral use.
For adults and pediatric patients (2 years and older)
Brompheniramine Maleate/Pseudoephedrine Hydrochloride Syrup
Each teaspoonful (5 mL) contains brompheniramine maleate, 4 mg; pseudoephedrine hydrochloride, 45 mg.
Inactive ingredients: citric acid, FD&C Red No. 40, glycerin, flavor, purified water, saccharin sodium, sodium benzoate, sodium citrate,
sorbitol.
Brompheniramine maleate (2-Pyridnepropanamine, y-(4-bromophenyl)- N, N-dimethyl-, (±)-, (Z)-2-butenedioate).
Pseudoephedrine hydrochloride (Benzenemethanol, α-[1-(methylamino)ethyl]-,[S-(R*,R*)]-, hydrochloride) is the hydrochloride of pseudoephedrine, a naturally occurring dextrorotatory stereoisomer of ephedrine.
Sildec Syrup - Clinical Pharmacology
Antihistaminic and decongestant actions.
Brompheniramine maleate possesses H1 antihistaminic activity and mild anticholinergic and sedative effects. Peak plasma concentration is reached in 5 hours. Urinary excretion is the major route of elimination. The liver is assumed to be the major site of metabolic transformation.
Pseudoephedrine hydrochloride is an oral sympathomimetic amine that acts as a decongestant to respiratory tract mucous membranes. While its vasoconstrictor action is similar to that of ephedrine, pseudoephedrine has less pressor eff..
