Siltuximab
Generic name: siltuximab [ sil-TUX-i-mab ]
Brand name: Sylvant
Dosage form: intravenous powder for injection (100 mg; 400 mg)
Drug class:Interleukin inhibitors
What is siltuximab?
Siltuximab is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.
Siltuximab is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.
Siltuximab may also be used for purposes not listed in this medication guide.
Warnings
You should not use siltuximab if you have a severe infection. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).
Before taking this medicine
You should not be treated with siltuximab if you are allergic to it, or if you have a severe infection.
If you have a severe illness with fever or any type of infection, you may need to wait until you get better before receiving siltuximab. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).
Tell your doctor if you have ever had:
a chronic infection;
a stomach or intestinal disorder, including ulcer or diverticulitis;
stomach or intestinal bleeding;
gout; or
if you have recently received any vaccines, or if you are due to receive one.
Siltuximab may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.
You should not breast-feed while using this medicine.
How is siltuximab given?
Siltuximab is given as an infusion into a vein, usually once every 3 weeks. A healthcare provider will give you this injection.
This medicine must be given slowly, and the infusion can take at least 1 hour to complete.
Siltuximab can increase your risk of bleeding or infection. You will need frequent medical tests. Your siltuximab treatments may be delayed based on the results.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your siltuximab injection.
What happens if I overdose?
Since siltuximab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving siltuximab?
Do not receive a "live" vaccine while using siltuximab. The vaccine may not work as well and may not fully protect ...
