Siltuximab (Intravenous)

Medically reviewed by Drugs.com. Last updated on May 10, 2022.

Commonly used brand name(s)

In the U.S.

Sylvant

Available Dosage Forms:

Powder for Solution

Pharmacologic Class: Monoclonal Antibody

Uses for siltuximab

Siltuximab injection is used to treat a rare blood disorder called multicentric Castleman's disease (MCD). Siltuximab is used in patients who do not have human immunodeficiency virus (HIV) and human herpes virus-8 (HHV-8) infection.

Siltuximab is to be given only by or under the direct supervision of your doctor.

Before using siltuximab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For siltuximab, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to siltuximab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of siltuximab injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of siltuximab injection in the elderly. However, elderly patients are more sensitive to the effects of siltuximab than younger adults.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving siltuximab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using siltuximab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Tofacitinib

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Siltuximab Intravenous