Sinecatechins

Class: Skin and Mucous Membrane Agents, Miscellaneous
CAS Number: 188265-33-0
Brands: Veregen

Medically reviewed by Drugs.com on Mar 25, 2022. Written by ASHP.

Introduction

Antioxidant; a green tea extract consisting predominantly of catechins.

Uses for Sinecatechins

External Genital and Perianal Human Papillomavirus Warts

Treatment of external genital and perianal warts (condylomata acuminata) caused by human papillomavirus (HPV) in immunocompetent patients.

CDC recommends that external HPV genital warts be treated with a self-administered topical therapy (imiquimod, podofilox, sinecatechins), a topical therapy administered by a health-care provider (podophyllum resin, trichloroacetic acid [TCA], bichloroacetic acid [BCA]), or a surgical technique (cryotherapy, electrosurgery, surgical excision).

Should not be used for treatment of urethral, intravaginal, cervical, rectal, or intra-anal HPV disease; safety and efficacy not established.

Sinecatechins Dosage and Administration

Administration

Topical Administration

Apply topically to the skin as a 15% ointment. For external use only.

Avoid contact with the eyes; do not administer orally, intravaginally, or intra-anally. Do not apply to open wounds.

Wash hands before and after application. Apply a thin layer to each wart with the finger(s), dabbing to ensure complete coverage. Do not use bandages, occlusive dressings, or wrappings.

Uncircumcised males treating warts under the foreskin should retract the foreskin and clean the area daily.

Washing ointment from the treated area prior to the next application is not necessary. If bathing or washing the treatment area, apply ointment afterwards. (See Advice to Patients.)

Dosage

Adults

HPV Infections

External Genital and Perianal HPV Warts

Apply a 0.5-cm strand of ointment to each wart 3 times daily, dabbing with fingers to ensure complete coverage and leaving a thin film on warts.

Continue therapy until all warts have completely cleared or for a maximum of 16 weeks.

Safety and efficacy of multiple treatment courses not established.

Prescribing Limits

Adults

HPV Infections

External Genital and Perianal HPV Warts

Maximum of 16 weeks.

Special Populations

No special population dosage recommendations.

Cautions for Sinecatechins

Contraindications

• No known contraindications.

Warnings/Precautions

Other Forms of HPV Disease

Safety and efficacy not est