Sinemet CR

Generic name:carbidopa and levodopa [ KAR-bi-DOE-pa-and-LEE-voe-DOE-pa ]
Brand names: Rytary, Sinemet, Sinemet CR
Drug class:Dopaminergic antiparkinsonism agents

Medically reviewed by Drugs.com on May 3, 2021. Written by Cerner Multum.

What is Sinemet CR?

Sinemet CR is a combination medicine used to treat symptoms of Parkinson's disease, such as stiffness or tremors.

Sinemet CR is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication.

Sinemet CR may also be used for purposes not listed in this medication guide.

Warnings

Do not use Sinemet CR if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Before taking this medicine

You should not use this medicine if you are allergic to carbidopa or levodopa, or if you have:

• narrow-angle glaucoma.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have ever had:

• heart disease, high blood pressure, or heart attack;

• liver or kidney disease;

• an endocrine (hormonal) disorder;

• asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;

• a stomach or intestinal ulcer;

• open-angle glaucoma; or

• depression, mental illness, or psychosis.

The disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

People with Parkinson's disease may have a high...