Siponimod
Generic name: siponimod [ sye-POE-ni-mod ]
Brand names: Mayzent, Mayzent Starter Pack
Dosage form: oral tablet (0.25 mg; 2 mg)
Drug class:Selective immunosuppressants
What is siponimod?
Siponimod is used to treat relapsing multiple sclerosis (MS) in adults. This medication will not cure MS, it will only decrease the frequency of relapse symptoms.
Siponimod is used only if you have a specific genotype. Your doctor will test you for this genotype.
Siponimod may also be used for purposes not listed in this medication guide.
Warnings
You should not use siponimod if you have a serious heart condition such as "AV block," sick sinus syndrome and no pacemaker, or if you've recently had heart block, heart failure, a heart rhythm disorder, chest pain, heart attack, or stroke.
Siponimod can slow your heart rate when you start taking it. You will receive your first dose in a setting where your heart rhythm can be monitored. If you miss any doses, you may also need to restart siponimod under medical observation.
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, aches, tiredness, vomiting, confusion, neck stiffness, increased sensitivity to light, or problems with coordination, thought, vision, or muscle movement.
Before taking this medicine
You should not use siponimod if you are allergic to it, or if you have certain serious heart conditions, especially:
"AV block" (2nd or 3rd degree);
sick sinus syndrome (unless you have a pacemaker);
recent (within the past 6 months) heart failure, heart attack, stroke, "mini-stroke" or TIA, chest pain (unstable angina), or other serious heart problem.
Siponimod is not approved for use by anyone younger than 18 years old.
Some heart rhythm medications can cause unwanted or dangerous effects when used with siponimod. Your doctor may change your treatment plan if you also use: amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, or
