Sirolimus

Generic name: sirolimus [ sih-RO-lim-us ]
Brand name: Rapamune
Dosage forms: oral solution (1 mg/mL); oral tablet (0.5 mg; 1 mg; 2 mg)
Drug classes:MTOR inhibitors, Selective immunosuppressants

Medically reviewed by Drugs.com on Feb 7, 2022. Written by Cerner Multum.

What is sirolimus?

Sirolimus weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Sirolimus is used with other medicines to prevent organ rejection after a kidney transplant.

Sirolimus is also given without other medicines to treat a rare lung disorder called lymphangioleiomyomatosis (lim-FAN-gee-oh-LYE-oh-MYE-oh-ma-TOE-sis). This disorder happens mostly in women and causes lung tumors that are not cancerous but can affect breathing.

Sirolimus may also be used for purposes not listed in this medication guide.

Warnings

You should not use sirolimus if you have ever had a lung transplant or liver transplant.

Sirolimus may cause your body to overproduce white blood cells. This can lead to cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure.

Call your doctor right away if you have: fever, flu symptoms, burning when you urinate, a new skin lesion, any change in your mental state, decreased vision, weakness on one side of your body, problems with speech or walking, or pain around your transplant.

Before taking this medicine

You should...