Sodium Sulfacetamide Scalp Treatment
Dosage form: topical lotion
Drug class:Topical antibiotics
Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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DESCRIPTION:
River’s Edge Scalp Treatment Lotion contains in each gram: 100mg Sulfacetamide Sodium, in an emulsion base containing Urea 10%, Polyethylene Glycol 400 Monostearate, Isopropyl Myristate, Propylene Glycol Monostearate, Propylene Glycol, Sodium Thiosulfate, Methyl Paraben, Tetrasodium EDTA and Purified Water. This bland lotion, containing surface active agents which allow the medication to come into intimate contact with the skin, is greaseless and disappears when rubbed into the skin or scalp. The hair can be combed and arranged as usual after application. The lotion rinses easily from the scalp with water.
Sulfacetamide sodium is C8H9N2NaO3S H20 with a molecular weight of 254.24. Chemically it is Acetamide, N-[(4-aminophenyl) sulfonyl]-, monosodium salt, monohydrate, with the following structural formula:
Sulfacetamide sodium is an odorless, white, crystalline powder with a bitter taste it is freely soluble in water, sparingly soluble in alcohol, while practically insoluble in benzene, in chloroform and in ether.
CLINICAL PHARMACOLOGY:
Sulfacetamide sodium exerts a bacteriostatic effect against sulfonamide-sensitive gram-positive and gram negative microorganisms commonly isolated from secondary cutaneous pyogenic infections. It acts by restricting the synthesis of folic acid required by bacteria for growth, by its competition with para-aminobenzoic acid. There are no clinical data available on the degree and rate of systemic absorption of River’s Edge 10% Sulfacetamide Sodium USP Scalp Treatment Lotion when applied to the skin or scalp. However, significant absorption of sulfacetamide sodium through the skin has been reported. The following in vitro data are available but their clinical significance is unknown. Organisms which show susceptibility to sulfacetamide sodium are: Streptococci, Staphylococci, E. coli, Klebsiella pneumoniae, Pseudomonas pyocyanea, Salmonella species, Proteus vulgaris, Nocardia and Actinomyces.
