Sodium Tetradecyl Sulfate Injection

Dosage form: injection, solution
Drug class:Sclerosing agents

Medically reviewed by Drugs.com. Last updated on Dec 1, 2020.

Sodium Tetradecyl Sulfate Injection Description

Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. The structural formula is as follows:

C 14H 29NaSO 4 7-Ethyl-2-methyl-4-hendecanol sulfate sodium salt MW 316.44

Sodium Tetradecyl Sulfate Injection is a sterile nonpyrogenic solution for intravenous use as a sclerosing agent.

3% 60 mg/2 mL (30 mg/mL): Each mL contains sodium tetradecyl sulfate 30 mg, benzyl alcohol 0.02 mL and dibasic sodium phosphate, anhydrous 9 mg in Water for Injection. pH 7.9; monobasic sodium phosphate and/or sodium hydroxide added, if needed, for pH adjustment.

Sodium Tetradecyl Sulfate Injection - Clinical Pharmacology

Sodium Tetradecyl Sulfate Injection is a sclerosing agent. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

Indications and Usage for Sodium Tetradecyl Sulfate Injection

Sodium Tetradecyl Sulfate Injection is indicated in the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves. The benefit- to-risk ratio should be considered in selected patients who are great surgical risks.

Contraindications

Sodium Tetradecyl Sulfate Injection is contraindicated in previous hypersensitivity reactions to the drug; in acute superficial thrombophlebitis; valvular or deep vein incompetence; huge superficial veins with wide open communications to deeper veins; phlebitis migrans; acute cellulitis; allergic conditions; acute infections; varicosities caused by abdominal and pelvic tumors unless the tumor has been removed; bedridden patients; such uncontrolled systemic diseases as diabetes, toxic hyperthyroidism, tuberculosis, asthma, neoplasm, sepsis, ...