Class: Mydriatics
ATC Class: S01FA01
VA Class: OP600
Chemical Name: Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8- azabicyclo-[3.2.1]oct-3-yl ester, endo-(±)-, sulfate (2:1) (salt), monohydrate
CAS Number: 5908-99-6
Brands: Atropine Care, Isopto Atropine
Introduction
Mydriatic and cycloplegic; naturally occurring tertiary amine antimuscarinic.
Uses for Atropine (EENT)
Ophthalmologic Examination
Used to produce mydriasis and cycloplegia for refraction (e.g., retina and optic disc examination, measurement of refractive error). However, because of long duration of action relative to that of other anticholinergic agents, atropine is seldom, if ever, used for cycloplegic refraction in adults.
In rare cases, ophthalmic atropine use may be necessary to achieve maximal cycloplegia in pediatric patients, but cyclopentolate is more frequently used.
Ophthalmic Inflammation
Management of acute inflammatory conditions (e.g., iridocyclitis) of the iris and uveal tract (e.g., uveitis).
Amblyopia
Used for cycloplegic effects in the treatment of suppression amblyopia (lazy eye) to reduce the visual acuity of the unaffected eye below that of the amblyopic one and force fixation with the amblyopic eye.
Excess Accommodation and Convergence
Used to treat patients with a functional excess of accommodation and convergence.
Atropine (EENT) Dosage and Administration
General
Prior to initiation of therapy, estimate the depth of the angle of the anterior chamber to avoid induction of angle-closure glaucoma in susceptible patients.
Administration
Ophthalmic Administration
Apply topically to eye(s) as an ophthalmic ointment or solution.
For topical ophthalmic use only. Not for injection.
Following topical application, apply finger pressure on the lacrimal sac for 2–3 minutes to avoid excessive systemic absorpt...
