Sudafed PE Severe Cold

Generic name:acetaminophen, diphenhydramine, and phenylephrine [ a-SEET-a-MIN-oh-fen, DYE-fen-HYE-dra-meen, and-FEN-il-EFF-rin ]
Brand names: Benadryl Allergy & Sinus Headache, Delsym Cough Plus Cold Night Time, Mucinex Fast-Max Night Time Cold and Flu, Sudafed PE Severe Cold, Theraflu Severe Cold & Cough Nighttime
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com on Sep 29, 2020. Written by Cerner Multum.

What is Sudafed PE Severe Cold?

Acetaminophen is a pain reliever and fever reducer. Diphenhydramine is an antihistamine. Phenylephrine is a decongestant.

Sudafed PE Severe Cold is a combination medicine used to treat cold and flu symptoms such as runny or stuffy nose, sneezing, cough, sore throat, headache, fever, and body aches.

There are many brands and forms of acetaminophen, diphenhydramine, and phenylephrine available. Not all brands are listed on this leaflet.

Sudafed PE Severe Cold may also be used for purposes not listed in this medication guide.

Warnings

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Use this medicine exactly as directed. An overdose of acetaminophen can damage your liver or cause death. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy. Some brands of Sudafed PE Severe Cold are not approved for use in anyone younger than 12 years old.

Drinking alcohol may increase your risk of liver damage while taking acetaminophen.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Before taking this medicine

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you dri...