Sulfamylon Cream

Generic name:mafenide acetate
Dosage form: cream
Drug class:Topical antibiotics

Medically reviewed by Drugs.com. Last updated on May 1, 2021.

Sulfamylon Cream Description

Sulfamylon Cream is a soft, white, nonstaining, water-miscible, anti-infective cream for topical administration to burn wounds.

Sulfamylon Cream spreads easily, and can be washed off readily with water. It has a slight acetic odor. Each gram of Sulfamylon Cream contains mafenide acetate equivalent to 85 mg of the base. The cream vehicle consists of cetyl alcohol, steryl alcohol, cetyl esters wax, polyoxyl 40 stearate, polyoxyl 8 stearate, glycerin, and water, with methylparaben, propylparaben, sodium metabisulfite, and edetate disodium as preservatives.

Chemically, mafenide acetate is α-Amino-ρ-toluenesulfonamide monoacetate and has the following structural formula:

Sulfamylon Cream - Clinical Pharmacology

Sulfamylon Cream, applied topically produces a marked reduction in the bacterial population present in the avascular tissues of second- and third-degree burns. Reduction in bacterial growth after application of Sulfamylon Cream has also been reported to permit spontaneous healing of deep partial-thickness burns, and thus prevent conversion of burn wounds from partial-thickness to full-thickness. It should be noted, however, that delayed eschar separation has occurred in some cases.

Absorption and Metabolism
Applied topically, Sulfamylon Cream diffuses through devascularized areas, is absorbed, and rapidly converted to a metabolite (ρ-carboxybenzenesulfonamide) which is cleared through the kidneys. SULFAMYLON is active in the presence of pus and serum, and its activity is not altered by changes in the acidity of the environment.

Antibacterial Activity
SULFAMYLON exerts bacteriostatic action against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes.

Indications and Usage for Sulfamylon Cream

Sulfamylon Cream is a topical agent indicated for adjunctive therapy of patients with second- and third-degree burns.

Contraindications

SULFAMYLON is contraindicated in patients who are h