Sulfatol SS Cream

Generic name:sulfacetamide sodium and sulfur
Dosage form: cream
Drug class:Topical antibiotics

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

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PRODUCT DESCRIPTION

Each gram of Sulfatol SS Cream with Sunscreens contains 100 mg of sodium sulfacetamide and 50 mg of sulfur. Sulfacetamide sodium is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent sulfur.

Chemically, sulfacetamide sodium is Acetamide, N-[(4-aminophenyl) sulfonyl], monosodium salt, monohydrate. The structural formula is:

INACTIVE INGREDIENTS

Avobenzone USP, Benzyl Alcohol NF, Cetyl Alcohol NF, Cocoglycerides, Dimethicone 200/100, Edetate Disodium USP, Fragrance, Glyceryl Stearate/PEG-100 Stearate, Isopropyl Myristate NF, Light Mineral Oil NF, Octinoxate USP, Polysorbate 60 NF, Propylene Glycol USP, Purified Water USP, Sodium Thiosulfate USP, Sorbitan Monostearate NF, Stearyl Alcohol NF, Xanthan Gum NF.

Sulfatol SS Cream - Clinical Pharmacology

The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sulfacetamide sodium is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.