Sulfisoxazole (Oral)

Medically reviewed by Drugs.com. Last updated on Jun 3, 2022.

Commonly used brand name(s)

In the U.S.

• Gantrisin Pediatric
• Truxazole

Chemical Class: Sulfonamide

Uses for sulfisoxazole

Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria. However, sulfisoxazole will not work for colds, flu, or other virus infections.

Sulfisoxazole is available only with your doctor's prescription.

Before using sulfisoxazole

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sulfisoxazole, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to sulfisoxazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Because of sulfisoxazole's toxicity, use in infants younger than 2 months of age is not recommended.

Geriatric

No information is available on the relationship of age to the effects of sulfisoxazole in geriatric patients. However, elderly patients are more likely to have age-related kidney and liver problems, which may require caution in patients receiving sulfadiazine.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sulfisoxazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using sulfisoxazole with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Methenamine

Using sulfisoxazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Methotrexate
• Porfimer
• Warfarin

Using sulfisoxazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetohexamide
• Aminolevulinic Acid

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause int...