Synalgos-DC
Generic name:aspirin, caffeine, and dihydrocodeine bitartrate
Dosage form: capsule
Drug class:Narcotic analgesic combinations
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE
Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.
The Synalgos-DC brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Synalgos-DC Description
Each Synalgos-DC capsule contains 16 mg drocode (dihydrocodeine) bitartrate (Warning–may be habit-forming), 356.4 mg aspirin, and 30 mg caffeine.
The inactive ingredients present are alginic acid, cellulose, D&C Red 28, FD&C Blue 1, gelatin, iron oxides, stearic acid, and titanium dioxide.
Synalgos-DC - Clinical Pharmacology
Dihydrocodeine is a semisynthetic narcotic analgesic, related to codeine, with multiple actions qualitatively similar to those of codeine; the most prominent of these involve the central nervous system and organs with smooth-muscle components. The principal action of therapeutic value is analgesia.
Synalgos-DC also contains the nonnarcotic antipyretic-analgesic, aspirin.
Indications and Usage for Synalgos-DC
For the relief of moderate to moderately severe pain.
Contraindications
Synalgos-DC is contraindicated for postoperative pain management in children who have undergone tonsillectomy and/or adenoidectomy.
Synalgos-DC is contraindicated in patients with hypersensitivity to dihydrocodeine, codeine, or aspirin
Warnings
Salicylates should be used with extreme caution in the presence of peptic ulcer or coagulation abnor...
