Syntocinon
Generic name:oxytocin
Dosage form: Injection, USP
Drug class:Uterotonic agents
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
Syntocinon®
(oxytocin) injection, USP
Caution: Federal law prohibits dispensing without prescription.
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The Syntocinon brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Syntocinon Description
Syntocinon® (oxytocin) is a synthetic, (1-6) cyclic nonapeptide. Chemically, oxytocin is designated as Glycinamide, L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl- L-leucy1-, cyclic (1-6)-disulfide.
The structural formula is:
Syntocinon® (oxytocin) injection is provided as a sterile solution for intravenous or intramuscular administration. Each 1 mL of solution contains 10 USP or International Units of oxytocin and the following inactive ingredients:
acetic acid, NF, qs to ..... pH 4 ± 0.3
alcohol, USP..... 0.61 % by vol.
chlorobutanol, NF .....,..... 0.5%
sodium acetate, USP ...,..... 1 mg
sodium chloride, USP ..... 0.017 mg
water for injection, USP, qs to ..... 1 mL
Syntocinon - Clinical Pharmacology
The pharmacologic and clinical properties of Syntocinon® (oxytocin) are identical with the naturally occurring oxytocic principle of the posterior lobe of the pituitary. Syntocinon® (oxytocin) injection does not contain the amino acids characteristic of vasopressin, and therefore has fewer and less severe cardiovascular effects. Syntocinon® (oxytocin) exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the tone of the uterine musculature.
Syntocinon® (oxytocin), when given in appropriate doses during pregnancy, is capable of eliciting graded increases...
