Tafenoquine (Arakoda)
Class: Antimalarials
Chemical Name: (4RS)-N4-{2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine
Molecular Formula: C24H28F3N3O3C24H28F3N3O3•C4H6O4
CAS Number: 106635-80-7
Brands: Arakoda
Introduction
Tafenoquine succinate is an antimalarial agent.
Uses for Tafenoquine (Arakoda)
Tafenoquine succinate has the following uses:
Tafenoquine succinate (Arakoda) is an antimalarial indicated for the prophylaxis of malaria in patients aged 18 years and older.
Tafenoquine (Arakoda) Dosage and Administration
General
Tafenoquine succinate (Arakoda) is available in the following dosage form(s) and strength(s):
Tablets: 100 mg of tafenoquine.
Clinicians should be aware that there are 2 different oral formulations of tafenoquine succinate with different indications and dosage regimens. The 100-mg tablets (e.g., Arakoda) are labeled for use for prophylaxis of malaria in adults; the 150-mg tablets (e.g., Krintafel) are labeled for use for the radical cure (prevention of relapse) of Plasmodium vivax malaria in adults and pediatric patients 16 years of age and older. Exercise caution to ensure that the appropriate dosage is used for the specific indication.
All patients must be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency prior to prescribing tafenoquine succinate.
Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with tafenoquine succinate.
Dosage
It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Adults
Dosage and Administration
Administer tafenoquine succinate with food.
Swallow tablets whole. Do not break, crush, or chew the tablets.
The recommended dosage of tafenoquine succinate (Arakoda) is described in Table 1 below. Tafenoquine succinate may be administered for up to 6 months of continuous dosing.
Regimen Name | Timing | Dosage |
Loading regimen | For each of the 3 days before travel to a malarious area | 200 mg (2 of the 100 mg tablets) once daily for 3 days |
Maintenance regimen | While in the malarious area | 200 mg (2 of the 100 mg tablets) once weekly; start 7 days after the last loading regimen dose |
Terminal prophylaxis regimen | In the week following exit from the malarious area | 200 mg (2 of the 100 ... MEDICAL DEPARTMENTS
Cardiology
Pediatrics
Diabetes Care
Pre-natal Care
Ultrasound Echocardiogram
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