Tafenoquine (Krintafel)

Class: Antimalarials
Chemical Name: (4RS)-N4-{2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine
Molecular Formula: C₂₄H₂₈F₃N₃O₃C₂₄H₂₈F₃N₃O₃•C₄H₆O₄
CAS Number: 106635-80-7
Brands: Krintafel

Medically reviewed by Drugs.com on Jan 25, 2022. Written by ASHP.

Introduction

Tafenoquine succinate is an antimalarial agent.

Uses for Tafenoquine (Krintafel)

Tafenoquine succinate has the following uses:

Tafenoquine succinate (Krintafel) is an antimalarial indicated for the radical cure (prevention of relapse) of Plasmodium vivax malaria in patients aged 16 years and older who are receiving appropriate antimalarial therapy for acute P. vivax infection.

Tafenoquine succinate has the following limitations of use:

Tafenoquine succinate (Krintafel) is NOT indicated for the treatment of acute P. vivax malaria.

Tafenoquine (Krintafel) Dosage and Administration

General

Tafenoquine succinate (Krintafel) is available in the following dosage form(s) and strength(s):

Tablets: 150 mg of tafenoquine.

Clinicians should be aware that there are 2 different oral formulations of tafenoquine succinate with different indications and dosage regimens. The 100-mg tablets (e.g., Arakoda) are labeled for use for prophylaxis of malaria in adults; the 150-mg tablets (e.g., Krintafel) are labeled for use for the radical cure (prevention of relapse) of Plasmodium vivax malaria in adults and pediatric patients 16 years of age and older. Exercise caution to ensure that the appropriate dosage is used for the specific indication.

All patients must be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency prior to prescribing tafenoquine succinate.

Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with tafenoquine succinate.

Dosage

It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:

Administer tafenoquine succinate with food to increase systemic absorption.

Swallow tablets whole. Do not break, crush, or chew the tablets.

In the event of vomiting within 1 hour after dosing, a repeat dose should be given. Re-dosing should not be attempted more than once.

Pediatric Patients

The recommended dose of tafenoquine succinate (Krintafel) in pediatric patients aged 16 years and older is a single dose of 300 mg administered as two 150-mg tablets taken together. Coadminister tafenoquine succinate on the first or second day of the appropriate antimalarial therapy (e.g. chloroquine) for acute P. vivax malaria.

Adults

The recommended dose of tafenoquine succinate (Krintafel) in adults is a single dose of 300 mg administered as two 150-mg tablets taken together. Coadmin...